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To comprehend how the corona
The study focused on the early impact of SARS-CoV-2 infection on human nasal epithelial cells (NECs). Epithelial cells, abundant throughout our bodies, play crucial roles in bodily functions and protection. Researchers cultured NECs to replicate the nasal cavity’s cellular environment and infected them with SARS-CoV-2.
Analysing cells from participants across various age brackets, including children (0-11 years), adults (30-50 years), and the
In contrast, NECs from older individuals exhibited increased viral replication, accompanied heightened cell shedding and damage. This disparity may explain why
Lead author Claire Smith explains, “Our research highlights age-related changes in nasal cells and their impact on our ability to combat SARS-CoV-2 infection. This insight is crucial for developing targeted antiviral treatments, especially for older adults who are at greater risk of severe COVID-19.”
Understanding age-specific differences in nasal cell response to SARS-CoV-2 could lead to targeted antiviral therapies that boost interferon production in older adults, potentially reducing the severity of COVID-19 and lowering mortality rates in this demographic.
Furthermore, the study underscores the importance of considering age as a significant factor in researching and treating infectious diseases. Beyond COVID-19, future studies should explore how
The research findings have been published in Nature Microbiology and can be accessed here.